Developmental Fluoride Neurotoxicity a Systematic Review and Meta-analysis

Review

. 2012 Oct;120(x):1362-8.

doi: ten.1289/ehp.1104912. Epub 2012 Jul 20.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis

Affiliations

• PMID: 22820538
• PMCID: PMC3491930
• DOI: ten.1289/ehp.1104912

Gratis PMC article

Review

Developmental fluoride neurotoxicity: a systematic review and meta-analysis

Anna Fifty Choi  et al. Environ Health Perspect. 2012 Oct .

Costless PMC article

Abstract

Background: Although fluoride may crusade neurotoxicity in fauna models and astute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children's neurodevelopment.

Objective: We performed a systematic review and meta-assay of published studies to investigate the furnishings of increased fluoride exposure and delayed neurobehavioral evolution.

Methods: We searched the MEDLINE, EMBASE, Water Resources Abstracts, and TOXNET databases through 2011 for eligible studies. We also searched the China National Cognition Infrastructure (CNKI) database, considering many studies on fluoride neurotoxicity have been published in Chinese journals just. In total, nosotros identified 27 eligible epidemiological studies with high and reference exposures, terminate points of IQ scores, or related cognitive part measures with ways and variances for the two exposure groups. Using random-effects models, we estimated the standardized mean divergence between exposed and reference groups across all studies. We conducted sensitivity analyses restricted to studies using the same consequence assessment and having drinking-water fluoride as the only exposure. We performed the Cochran examination for heterogeneity between studies, Begg's funnel plot, and Egger examination to assess publication bias, and conducted meta-regressions to explore sources of variation in hateful differences among the studies.

Results: The standardized weighted mean divergence in IQ score between exposed and reference populations was -0.45 (95% confidence interval: -0.56, -0.35) using a random-furnishings model. Thus, children in high-fluoride areas had significantly lower IQ scores than those who lived in low-fluoride areas. Subgroup and sensitivity analyses also indicated inverse associations, although the substantial heterogeneity did not appear to decrease.

Conclusions: The results back up the possibility of an agin result of high fluoride exposure on children's neurodevelopment. Hereafter research should include detailed individual-level data on prenatal exposure, neurobehavioral performance, and covariates for adjustment.

Disharmonize of involvement statement

The authors declare they have no actual or potential competing financial interests.

Figures

Figure 1

Menstruum diagram of the meta-analysis.

Figure 2

Random-consequence standardized weighted mean difference (SMD) estimates and 95% CIs of child's intelligence score associated with loftier exposure to fluoride. SMs for individual studies are shown equally solid diamonds (♦), and the pooled SMD is shown equally an open diamond (◊). Horizontal lines represent 95% CIs for the written report-specific SMDs.

Figure iii

Begg's funnel plot showing individual studies included in the analysis according to random-effect standardized weighted mean divergence (SMD) estimates (x-axis) and the SE (se) of each report-specific SMD (y-axis). The solid vertical line indicates the pooled SMD estimate for all studies combined and the dashed lines indicated pseudo 95% confidence limits effectually the pooled SMD gauge.

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Source: https://pubmed.ncbi.nlm.nih.gov/22820538/

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